CALL FOR PAPERS Aldosterone and Epithelial Na Channels Defining an inhibitory domain in the -subunit of the epithelial sodium channel
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چکیده
Marcelo D. Carattino, Christopher J. Passero, Carlos A. Steren, Ahmad B. Maarouf, Joseph M. Pilewski, Mike M. Myerburg, Rebecca P. Hughey, and Thomas R. Kleyman Renal-Electrolyte Division and Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, and Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania; and NMR Facility, Department of Chemistry, University of Tennessee, Knoxville, Tennessee
منابع مشابه
Salt, sodium channels, and SGK1.
The hormone aldosterone increases extracellular fluid volume and blood pressure by activating epithelial Na+ channels (ENaCs). Serum- and glucocorticoid-induced kinase 1 (SGK1) is an aldosterone-stimulated signaling molecule that enhances distal nephron Na+ transport, in part by preventing the internalization of ENaCs from the plasma membrane. In this issue of the JCI, Zhang et al. demonstrate ...
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Frindt G, Palmer LG. Regulation of epithelial Na channels by adrenal steroids: mineralocorticoid and glucocorticoid effects. Am J Physiol Renal Physiol 302: F20–F26, 2012. First published October 19, 2011; doi:10.1152/ajprenal.00480.2011.—Epithelial Na channels (ENaC) can be regulated by both mineralocorticoid and glucocorticoid hormones. In the mammalian kidney, effects of mineralocorticoids h...
متن کاملGamma subunit second transmembrane domain contributes to epithelial sodium channel gating and amiloride block.
The epithelial sodium channel (ENaC) is comprised of three homologous subunits. Channels composed solely of α- and β-subunits (αβ-channels) exhibit a very high open probability (Po) and reduced sensitivity to amiloride, in contrast to channels composed of α- and γ-subunits or of all three subunits (i.e., αγ- and αβγ-channels). A mutant channel comprised of α- and β-subunits, and a chimeric γ-su...
متن کاملCALL FOR PAPERS Aldosterone and ENaC: From Genetics to Physiology Regulation of Na transport by aldosterone: signaling convergence and cross talk between the PI3-K and MAPK1/2 cascades
Tong, Qiusheng, Rachell E. Booth, Roger T. Worrell, and James D. Stockand. Regulation of Na transport by aldosterone: signaling convergence and cross talk between the PI3-K and MAPK1/2 cascades. Am J Physiol Renal Physiol 286: F1232–F1238, 2004. First published March 23, 2004; 10.1152/ajprenal.00345. 2003.—Cross talk between the phosphatidylinositol 3-kinase (PI3-K) and mitogen-activating prote...
متن کاملDefining an inhibitory domain in the gamma subunit of the epithelial sodium channel.
Proteases activate the epithelial sodium channel (ENaC) by cleaving the large extracellular domains of the α- and γ-subunits and releasing peptides with inhibitory properties. Furin and prostasin activate mouse ENaC by cleaving the γ-subunit at sites flanking a 43 residue inhibitory tract (γE144-K186). To determine whether there is a minimal inhibitory region within this 43 residue tract, we ge...
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